Chinese medicinal fungus shows promise in treating idiopathic pulmonary fibrosis

A leer from China has reported that Cordyceps sinensis (CS), a primitive Chinese medicinal fungus, can ameliorate idiopathic pulmonary fibrosis (IPF) in mice by inhibiting mitochondrion-mediated oxidative stress.

The analysis, performed by a team led by Huan Tang and Jigang Wang from the Institute of Chinese Materia Medica at the China Academy of Chinese Scientific Sciences, became as soon as printed in MedComm-Future Treatment.

Idiopathic pulmonary fibrosis is a continual and progressive lung illness characterised by a decline in lung characteristic, indirectly leading to respiratory failure and a vastly diminished quality of lifestyles for patients. With a median survival duration of two to 5 years put up-diagnosis, there might perhaps be an urgent need for efficient therapies previous the fresh anti-fibrotic medicines, which will be connected to unfavorable outcomes.

The leer crucial aspects how CS, identified for its antioxidant and anti-inflammatory properties, became as soon as came at some stage in to mitigate pulmonary inflammation and collagen deposition in a mouse mannequin of IPF.

Proteomic prognosis printed that CS’s therapeutic receive will be attributed to the legislation of mitochondrial oxidative phosphorylation, suggesting a doubtless holding mechanism towards IPF.

The analysis team’s findings point to that CS now no longer handiest reduces the manufacturing of mitochondrial reactive oxygen species (mitROS) nonetheless also mitigates oxidative stress and inflammation by concentrated on mitochondrial complexes I and II.

These mechanisms make a contribution to the therapeutic receive of CS in pulmonary fibrosis, offering a promising replacement for patients littered with this debilitating illness.

The leer concludes that CS has the functionality to be a novel therapeutic agent for IPF, with its outcomes validated thru each in vivo and in vitro experiments. Nonetheless, the authors acknowledge the necessity for extra analysis to title the explicit parts in CS guilty for its therapeutic outcomes and to make clear the detailed mechanisms of its action.

More knowledge:
Ying Zhang et al, Cordyceps sinensis ameliorates idiopathic pulmonary fibrosis in mice by inhibiting mitochondrion‐mediated oxidative stress, MedComm – Future Treatment (2024). DOI: 10.1002/mef2.91

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Sichuan International Scientific Trade and Promotion Association